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SMAD7 | Colorectal Cancer October 31, 2007

Posted by ramunas in cancer genetics, colorectal cancer, genetic testing, research.
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A message is simple: variants (SNP’s) in SMAD7 gene (which is involved in TGF-beta and Wnt signaling; shown in red on the left side) influence colorectal cancer (CRC) risk.

Particulary association between rs4939827 and CRC was highly statistically significant. This study was performed by UK researchers and just published in Nature Genetics.

Just another SNP for future personalized genomic screen and risk assessment.

(image source)

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Comments»

1. Gene Genie #19: Geneticalization « ScienceRoll - November 4, 2007

[...] Janavičius at Cancer-Genetics examines the single nucleotides polymorphisms of the gene SMAD7 which is important in scleroderma as [...]

2. deCODE’ing Predisposition to Cancer « www.cancer-genetics.com - November 17, 2007

[...] Colorectal cancer. Includes the variants on chromosome 8 and in the SMAD7 gene and interpretation of their associated risk for the development of colorectal [...]


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