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Nomogram vs GeneSearch Genetic Test | Breast Cancer August 23, 2007

Posted by ramunas in bio-software, breast cancer, cancer genetics, GeneSearch.
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Several days ago an article from Memorial Sloan-Kettering Cancer Center, NY, USA, presented a user-friendly prediction model (nomogram) based on a large data set to assist in predicting the presence of sentinel lymph node (SLN) metastasis for a specific patient, which is important prognostic factor.

After multivariate analysis with SLN metastasis were associated several factors: age, tumor size, tumor type, lymphovascular invasion, tumor location, multifocality, and estrogen and progesterone receptors [ref.]. The nomogram was accurate, discriminating and properly validated (a model was subsequently applied to 1,545 sequential SLN biopsies.)

Because newly diagnosed breast cancer patients are increasingly interested in information about their disease, this validated nomogram for risk estimation could be useful tool for physicians and patients to accurately predict the likelihood of SLN metastasis.

A nice computerized version (Macromedia Flash 6.0) of the nomogram is available on their website.

This tool, known as a nomogram, can be used to calculate the likelihood that breast cancer that has spread to the sentinel lymph nodes has also spread to additional lymph nodes under the arm (axilla). It is designed to individualize the risk estimate for each patient — a key factor in deciding whether additional surgery is likely to be beneficial, website states.

Obviously, it is not a substitute for medical advise, diagnosis or treatment but seems to be quite useful addition for risk estimation.

Researchers recommends that this tool should be used by physicians only. Patients should use this tool only in consultation with their physicians.

Also, I think it would be of great interest to compare this Breast Cancer Nomogram results with recently FDA approved Johnson&Johnsons GeneSearch™ Breast Lymph Node (BLN) assays results, which claims to detect the spread of breast cancer into the lymph nodes by analyzing the level of metastatic tumor expression markers.

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