Update on Research | CIMBA & BRCA Trial September 5, 2007Posted by ramunas in BRCA, breast cancer, cancer genetics, genetic testing, hereditary cancer, research.
Just let you know about some updates in Research section (all in UK):
- CIMBA (from Cambridge Genetic Epidemiology Unit and stands for “Consortium of Investigators of Modifiers of BRCA1/2″) is an international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers. The aim of CIMBA is to provide sufficient sample sizes to allow large scale studies in order to evaluate reliably the effects of genetic modifiers. It is sure, that identification of genetic modifiers of breast cancer risk for BRCA1 and BRCA2 mutation carriers will lead to an improved understanding of breast cancer. This knowledge may prove useful for the determination of individualized risk of cancer amongst carriers, who have significantly increased, but variable, risk for breast, ovarian and some other cancers.
Any group can contribute to research if can provide at least 92 BRCA1 and BRCA2 mutation carriers genotype and risk factors data. Currently there is a list of 27 international groups contributing to research.
Recently there was the first report published in Cancer Epidemiology Biomarkers & Prevention , where the F31I polymorphism in AURKA oncogene, which previously has been associated with breast cancer risk in the homozygous state, was not found to be associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers. A total of 4,935 BRCA1 and 2,241 BRCA2 mutation carriers and 11 individuals carrying both BRCA1 and BRCA2 mutations were genotyped for F31I.
A review of CIMBA is available at Breast Cancer Research.
- The BRCA Trial (an international trial supported by Breakthrough & Cancer Research UK), which is interested in developing and improving individualized treatments for a specific type of hereditary breast cancer (again for BRCA1 and BRCA2 carriers).
The cancer research is an important field to gain a new knowledge not only in cancer genetics. And if somebody would like to support it, should consider buying pinky Nokia’s phone or Belkin’s Apple iPod 🙂