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Colon cancer gene expression | Genomic Health January 30, 2008

Posted by ramunas in cancer genetics, colon cancer, genetic testing, sporadic cancer.

The producers (Genomic Health) of breast cancer recurrence 21 gene expression test Oncotype DX (launched in 2004) recently reported the results of two studies, which found genes that could help predict the likelihood of recurrence of and chemotherapy benefit for early-stage colon cancer (via).

Results of the studies were presented January 26, 2008 at ASCO GI, the American Society of Clinical Oncology’s Gastrointestinal Cancers Symposium, in Orlando, Florida.

Both study reports used Genomic Health’s quantitative RT-PCR to analyze RNA expression for 375 cancer-related and reference genes from colon tumors of patients who were treated with surgery alone or with surgery and adjuvant 5-fluorouracil/leucovorin (5-FU/LV) chemotherapy (ref.).

In first study (765 + 270 patients) and researchers found 65 genes significantly associated with colon cancer recurrence across – the individual gene expression was associated with an up to 11-fold difference in the risk of disease recurrence (via).

The second study analyzed colon cancers from an additional 508 patients who were treated with surgery plus 5-FU/LV chemotherapy. Fifty six genes were discovered that were significantly associated with disease prognosis for stage II and III colon cancer

Fifteen of the 56 genes were also used as a preliminary model to stratify patients into recurrence-risk categories (via).

Overall, Genomic Health has completed four independent studies involving 1,851 colon cancer patients to evaluate a total of 761 genes. This data will support the selection of the final gene set (ref).

Not long is to wait for the new test (an analog to breast cancer Oncotype DX) to personalize treatment decisions for early-stage colon cancer patients.



1.   Colon cancer gene expression | Genomic Health by medTRIALS.info - January 30, 2008

[…] post by ramunas delivered by Medtrials and […]

2. Paul - colon cancer chemotherapy - August 10, 2010

Inherited colon cancer is an issue that both men and women need to be concerned about. Since this type of cancer is part of the DNA coding there is nothing you can do prevent the fact that you may have it. However, you can get tested for inherited colon cancer and therefore your doctor can help you prevent it from affecting your lifestyle.

Even though inherited colon cancer is still a major ailment in or society, the number of deaths from it continue to drop due to various types of testing that have been implemented over the past 15 years. Early screenings at annual check ups can identify any development of polyps. The removal of them will prevent colon cancer from starting and from spreading.

3. chemotherapy colon - October 24, 2010

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